Correlation Between the Polymorphism ofβ2 AR and the Labor Progress After Labor Analgesia

Nanjing Medical University

Status: Unknown

Conditions: Labor Analgesia

Treatments: Genetic: β2AR polymorphism

Study type: Observational

Funder types: Other

Identifiers

NCT02708602

NMCHC2016003

Details and patient eligibility

About

Labor and delivery is a unique physiological experience of women. Inappropriate length of labor progress during vaginal delivery may produce great risks for mother and fetus. Especially the slow progress is one of the most important reasons for the occurrence of cesarean section during vaginal delivery, which still with a high incidence in recent years.Previous studies have found that there was a significant correlation between the genetic polymorphisms of β 2-adrenergic receptor (β2AR) and the duration of vaginal delivery.Therefore, the researchers intend to investigate the distribution of β2-adrenergic receptor (β2AR) genetic polymorphisms among Chinese parturient and observe the relationship between the genetic polymorphisms and labor process after labor analgesia.

Enrollment: 300 estimated patients

Sex: Female

Ages: 23 to 43 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Nulliparous women
• Required labor analgesia
• Chinese
• Spontaneous labor

Exclusion criteria

• Contraindications for epidural analgesia
• Allergic to opioids and/or local anesthetics
• Failed to performing epidural catheterization
• Organic dysfunction
• Those who were not willing to or could not finish the whole study at any time
• Using or used in the past 14 days of the monoamine oxidase inhibitors
• Alcohol addictive or narcotic dependent patients
• Subjects with a nonvertex presentation or scheduled induction of labor
• Twin gestation and breech presentation

Trial design

300 participants in 6 patient groups

β2AR Arg16Arg (AA group)

Description:

People with β2AR Arg16Arg genotype.

Treatment:

Genetic: β2AR polymorphism

β2AR Arg16Gly (AG group)

Description:

People with β2AR Arg16Gly genotype.

Treatment:

Genetic: β2AR polymorphism

β2AR Gly16Gly (GG group)

Description:

People with β2AR Gly16Gly genotype.

Treatment:

Genetic: β2AR polymorphism

β2AR Gln27Gln (CC group)

Description:

People with β2AR Gln16Gln genotype.

Treatment:

Genetic: β2AR polymorphism

β2AR Gln27Glu (CG group)

Description:

People with β2AR Gln27Glu genotype.

Treatment:

Genetic: β2AR polymorphism

β2AR Glu27Glu (GG group)

Description:

People with β2AR Glu27Glu genotype.

Treatment:

Genetic: β2AR polymorphism