Correlation of Albuminuria With Arterial Stiffness

Istanbul University

Status: Completed

Conditions: Hypertension; Diabetes Mellitus; Vascular Stiffness; Albuminuria

Study type: Observational

Funder types: Other

Identifiers

NCT01041599

4154

Details and patient eligibility

About

The investigators aim to investigate the relationship between albuminuria and arterial stiffness in diabetic patients, hypertensive patients and healthy subjects.

Full description

CONTEXT: Albuminuria is an important cardiovascular risk factor. Arterial stiffness also gives important information about atherosclerosis. Oscillometric methods may be useful in assessing arterial stiffness in a mainly operator independent way.

OBJECTIVE: We aim to investigate the relationship between albuminuria and arterial stiffness measured with an oscillometric device in diabetic patients, hypertensive patients and healthy subjects.

METHODS: 152 diabetic patients, 152 hypertensive patients and 152 healthy subjects are planned to be enrolled in this study. The measurements will be done between 9:00 and 13:00. After the measurements, blood and urine samples will be obtained, centrifugated and kept in -80°C until assayed. Afterwards, echocardiographic left ventricle mass index will be calculated. The correlation between albuminuria and arterial stiffness will be assessed as the primary outcome measure.

Enrollment: 152 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diabetes Mellitus
• Hypertension
• Healthy subjects

Exclusion criteria

• Symptomatic cardiovascular diseases (heart failure, history of myocardial infarction, etc.)
• Renal failure
• Pregnancy
• Diseases of the aorta

Trial design

152 participants in 3 patient groups

Diabetic patients

Description:

Hypertensive and normotensive patients with type 2 diabetes mellitus

Hypertensive patients

Description:

Patients with essential hypertension

Healthy subjects

Description:

Healthy subjects