Correlation of Albuminuria With Arterial Stiffness

I

Istanbul University

Status

Completed

Conditions

Hypertension
Diabetes Mellitus
Vascular Stiffness
Albuminuria

Study type

Observational

Funder types

Other

Identifiers

NCT01041599
4154

Details and patient eligibility

About

The investigators aim to investigate the relationship between albuminuria and arterial stiffness in diabetic patients, hypertensive patients and healthy subjects.

Full description

CONTEXT: Albuminuria is an important cardiovascular risk factor. Arterial stiffness also gives important information about atherosclerosis. Oscillometric methods may be useful in assessing arterial stiffness in a mainly operator independent way. OBJECTIVE: We aim to investigate the relationship between albuminuria and arterial stiffness measured with an oscillometric device in diabetic patients, hypertensive patients and healthy subjects. METHODS: 152 diabetic patients, 152 hypertensive patients and 152 healthy subjects are planned to be enrolled in this study. The measurements will be done between 9:00 and 13:00. After the measurements, blood and urine samples will be obtained, centrifugated and kept in -80°C until assayed. Afterwards, echocardiographic left ventricle mass index will be calculated. The correlation between albuminuria and arterial stiffness will be assessed as the primary outcome measure.

Enrollment

152 patients

Sex

All

Ages

18 to 90 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Diabetes Mellitus
  • Hypertension
  • Healthy subjects

Exclusion criteria

  • Symptomatic cardiovascular diseases (heart failure, history of myocardial infarction, etc.)
  • Renal failure
  • Pregnancy
  • Diseases of the aorta

Trial design

152 participants in 3 patient groups

Diabetic patients
Description:
Hypertensive and normotensive patients with type 2 diabetes mellitus
Hypertensive patients
Description:
Patients with essential hypertension
Healthy subjects
Description:
Healthy subjects

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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