Correlation of Blood Gene Expression (TruGraf Liver) With Liver Biopsy in Pediatric Liver Transplant Recipients

Children's Mercy Hospital Kansas City

Status: Terminated

Conditions: Liver Transplant; Complications; Liver Failure, Acute

Treatments: Diagnostic Test: TruGraf® Liver gene expression panel (GEP)

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT06263114

00002826

Details and patient eligibility

About

Liver transplant rejection is when the body's immune system attacks and damages the liver of a transplant recipient. Currently the best way to see if that is happening is with a liver biopsy. The purpose of this research study is to see if a simple blood test can diagnose if a transplanted liver is being rejected.

Full description

This study is an investigator-initiated, prospective, single-cohort trial to assess the ability of the TruGraf® Liver gene expression panel (GEP) to predict rejection in pediatric liver transplant recipients undergoing surveillance and for-cause liver biopsy.

Enrollment: 16 patients

Sex: All

Ages: 1 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All liver transplant patients at least 1 year of age and less than 18 years of age undergoing surveillance or for-cause liver biopsy

Exclusion criteria

• Non-English, non-Spanish Speaking

Trial design