Correlation of Clinical and Laboratory Findings and Diuretic Efficacy in Patients With Edematous States in the Emergency Department

University of Cologne

Status: Completed

Conditions: Edema

Treatments: Other: Characterization of parameters of medical history, examination and diagnostics.

Study type: Observational

Funder types: Other

Identifiers

NCT03967717

Protocol 1.0

Details and patient eligibility

About

The aim of the study is the characterization of parameters from medical history, physical examination and diagnostics, which correlate with and could be used to predict diuretic efficacy.

Full description

This prospective observational study is conducted to identify and further isolate possible predictors for the efficacy of diuretics and to identify potential new predictors.

The study also observes if specific diuretic regimes (e.g. combination of loop diuretics and distal effective diuretics for sequential nephron blockade) have a greater diuretic effect. This is not yet proved.

The data of the study shall to help to determine criteria, allowing to choose an effective diuretic regime in different patient cohorts already at the beginning of therapy and to identify patients at high risk.

Enrollment: 102 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age over 18 years.
• Edema (peripheral and/or pulmonal) of cardiac or renal genesis.

Exclusion criteria

• Persons who are in a dependency/employment relationship with the investigators.
• Accommodation in an institution by judicial or administrative order.
• Patients in need of ascites puncture and/or thoracentesis on admission day.

Trial design

102 participants in 1 patient group

Patients with edematous states

Description:

Patients with edematous states receive standard of care diuretic.

Treatment:

Other: Characterization of parameters of medical history, examination and diagnostics.