Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery Disease

Aristotle University Of Thessaloniki

Status: Unknown

Conditions: Coronary Artery Disease; Coronary Arteriosclerosis; Cardiovascular Risk Factor

Treatments: Genetic: SNPs associated with CAD

Study type: Observational

Funder types: Other

Identifiers

NCT03315234

CIP_PhD Rampidis Georgios_1.1

Details and patient eligibility

About

The purpose of the research project is to investigate the potential association of 6 genetic polymorphisms with the complexity and the severity of coronary artery disease (SYNTAX score). The aim of the study is to combine genetic, clinical and laboratory data in order to create a prognostic tool that will enable an individualized therapeutic patient approach.

Full description

This study focus on the prediction of future risk of cardiovascular events, assessing the severity and complexity of coronary artery disease by incorporating genetic information into the SYNTAX score and providing personalized therapeutic guidance to patients. The ultimate goal of the study would be to identify, design and develop a panel of genetic markers that in combination with clinical and angiographic information will be a reliable tool for predicting cardiovascular risk for future adverse events. Clinical and genetic patient information are systematically collected in a fashion that will enable also retrospective evaluation.

Enrollment: 270 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients who are admitted in the Department of Cardiology in the AHEPA University General Hospital of Thessaloniki and undergo coronary angiography for clinical purposes
2. Patients giving voluntary written consent to participate in the study
3. Male or female patients between 18 years to 90 years at entry
4. Patients without previous history of CAD

Exclusion criteria

1. Patients < 18 years old and > 90 years old at time of coronary angiography
2. Patients with a previous history of CAD
3. Cardiac Arrest at admission
4. Patients with serious concurrent disease and life expectancy of < 1 year
5. Patients who refuse to give written consent for participation in the study

Trial design

270 participants in 3 patient groups

SYNTAX score = 0

Description:

Patients with nonobstructive CAD (≤50 % diameter stenosis)

Treatment:

Genetic: SNPs associated with CAD

0 < SYNTAX score < 23

Description:

Low SYNTAX group

Treatment:

Genetic: SNPs associated with CAD

SYNTAX score ≥ 23

Description:

Intermediate-High SYNTAX group

Treatment:

Genetic: SNPs associated with CAD