Correlation of Peritoneal Fluid CA-125 Levels With Postoperative Tumor Histology

Erdemli State Hospital

Status

Completed

Conditions

Endometrial Carcinoma

Treatments

Diagnostic Test: abdominal fluid CA-125 levels test

Study type

Interventional

Funder types

Other

Identifiers

NCT04830332

CA125

Details and patient eligibility

About

In this prospective study, we aimed to investigate whether serum and abdominal washing fluid CA-125 levels correlated with postoperative histopathological parameters in patients with endometrial carcinoma.

Full description

Endometrial cancer was diagnosed with histopathological examination of the samples obtained by dilatation and curettage. Preoperative serum CA-125 levels were determined in all patients. Serum and abdominal washing fluid CA-125 levels were measured with a double antibody sandwich immunoenzymatic method, using Beckman Coulter DXI (Ireland) analyzer. In addition to routine preoperative investigations, MRI was done in patients who were thought to have an extension outside the uterus.

During surgery, abdominal exploration was performed first, and then an abdominal fluid sample was obtained for cytological examination and measurement of CA-125 level. One hundred milliliters of normal saline was used as the abdominal washing liquid to obtain the sample for CA-125 measurement. Subsequently, total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH + BSO) were performed.

Enrollment

50 patients

Sex

Female

Ages

55 to 68 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Women with endometrial carcinoma

Exclusion criteria

Previous history of any other malignancy
Endometriosis
Diagnosed with pelvic infection or with any other potential disease such as acute pancreatitis, colitis, diverticulitis, pericarditis, polyarteritis nodosa, Sjögren's syndrome and SLE