Correlation of Serum Adropin to Testosterone and Adiponectin in Obese Men

Aswan University Hospital

Status: Completed

Conditions: Dyslipidemias; Obesity

Treatments: Diagnostic Test: Adropin; Diagnostic Test: Adiponectin; Diagnostic Test: lipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL)); Diagnostic Test: Total testosterone

Study type: Observational

Funder types: Other

Identifiers

NCT03724825

Adropin in obese men

Details and patient eligibility

About

Obesity is associated with low testosterone in men and with dyslipidemia. Adropin hormone is negatively correlated with body mass index and is associated with dyslipidemia.

correlation between adropin and testosterone will be evaluated.

Full description

Obesity, a worldwide epidemic is associated with multiple adverse health outcome as diabetes mellitus, hypertension and cardiovascular diseases caused mainly by dyslipidemia linked to obesity. Low testosterone levels in obese men were found associated with dyslipidemia.

Adropin is a new metabolic hormone that was first isolated in liver and brain tissues, It was observed that mice fed on a high-fat diet (HFD) had a rapid increase in adropin expression compared to control values. In human also, adropin levels were negatively correlated with body mass index (BMI) and were associated with dyslipidemia.

Adiponectin is a protein that is mainly produced by white adipose tissue and has an important role in lipid metabolism. Serum adiponectin concentrations were decreased in obese compared to normal weight men and significantly correlated with testosterone level.

Enrollment: 82 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Age from 18 years to 50 years. Clinically free except from obesity

Exclusion criteria

• Diabetes mellitus Hypertension Heart failure Kidney disease Smoking

Trial design

82 participants in 2 patient groups

obese men

Description:

Adult obese men (BMI ≥ 30 kg/m2)

Treatment:

Diagnostic Test: Adropin

Diagnostic Test: Total testosterone

Diagnostic Test: lipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL))

Diagnostic Test: Adiponectin

normal men

Description:

normal weight men (18.5 ≤ BMI \< 25 kg/m2 )

Treatment:

Diagnostic Test: Adropin

Diagnostic Test: Total testosterone

Diagnostic Test: lipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL))

Diagnostic Test: Adiponectin