Correlation of Several Formulas to Evaluate Insulin Sensitivity With the Predicted M Index

University of Guadalajara

Status: Completed

Conditions: Healthy Lifestyle

Study type: Observational

Funder types: Other

Identifiers

NCT04010370

PREDIM-insulin sensitivity

Details and patient eligibility

About

Recently, an index based on the oral insulin sensitivity index with glucose (OGIS) has been proposed in combination with anthropometric variables, called PREDIcted M (PREDIM), however, there is no evidence of the correlation of this with respect to the various indices (McAuley, Belfiore, Cederholm, Avignon, Matsuda, Gutt, Stumvoll, HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), ISI (Insulin Sensitivity Index), Raynaud, QUICKI (The quantitative insulin sensitivity check index), FIRI (Fasting Insulin Resistance Index), Bennett, TyG (triglycerides and glucose index)) in healthy patients.

Full description

Analytical cross-sectional study with 25 healthy patients of both genders (male and female) from 30 to 60 years old, residents of the metropolitan area of Guadalajara.

They will be operated on for a 3-hour oral glucose tolerance test. The insulin sensitivity will be calculated with the PREDIM, Matsuda, McAuley, Belfiore, Cederholm, Avignon, Gutt, Stumvoll, HOMA-IR, ISI, Raynaud, QUICKI, FIRI, Bennett and TyG indexes.

This protocol is already approved by the local ethics committee and written informed consent it's going to be obtained from all volunteers.

The statistical analysis will be presented with measures of central tendency and dispersion, mean and standard deviation. The nominal variables in numbers and percentages. The Kolmogorov-Smirnov test will be performed to determine if the variables follow a normal distribution. To correlate the formulas used to evaluate the insulin sensitivity with the PREDIcted M (PREDIM) technique, the Pearson or Spearman correlation will be used according to the distribution.

Enrollment: 25 patients

Sex: All

Ages: 30 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Both genres
• Age 30 to 60 years
• BMI <25 kg / m2,
• Patients who are not sedentary or who participate in heavy physical activities
• Stable weight in the last 3 months

Exclusion criteria

• Blood pressure >120/80 mmHg
• Glucose >100 mg/dL
• Postprandial glucose >140 mg/dL
• Cholesterol >200 mg/dL
• Triglycerides >150 mg/dL
• Smoking
• Women with polycystic ovarian syndrome
• History of metabolic, cardiovascular, thyroid, renal, pancreatic and/or arterial hypertension
• Use of medications that modify insulin sensitivity (corticosteroids)
• Previous surgery or infection
• Symptoms of vomiting and/or excessive nausea

Trial design

25 participants in 1 patient group

Healthy individuals

Description:

Cross-Sectional. No intervention. Patients of both sexes who are not sedentary or who participate in heavy physical activities and residents of the metropolitan area of Guadalajara