Correlation of Tractography and Motor Evoked Potentials in Deep Brain Stimulation

Nova Scotia Health Authority (NSHA)

Status: Enrolling

Conditions: Improving Accuracy of Implanting Stimulation Electrodes

Treatments: Procedure: Deep Brain Stimulation

Study type: Observational

Funder types: Other

Identifiers

NCT03136302

DBS2017

Details and patient eligibility

About

The goal is to establish another anatomical referencing system in order to achieve an even higher accuracy when implanting stimulation electrodes.

Full description

The main goal is to find out what are the optimal distances to these reference fiber tracts when stimulating and to find the optimal target. This has to be evaluated for each target, such as globus pallidus (Gpi), subthalamic nucleus (STN) and ventral intermediate nucleus of the thalamus (VIM) separately. This is of special importance as the investigators can demonstrate the internal capsule, which is often a generator of stimulation-induced side effects: tetanic muscle contractions, dysarthria and gaze deviations.

Enrollment: 60 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient qualifying for deep brain stimulation on the basis of a movement disorder (Parkinson's Disease, tremor, dystonia) or chronic pain disease.
• Informed consent

Exclusion criteria

• Lack of consent
• Electrical or other devices that preclude the performance of an MRI

Trial design

60 participants in 3 patient groups

Subthalamic Nucleus (STN)

Description:

Patients with Parkinson's disease

Treatment:

Procedure: Deep Brain Stimulation

Globus Pallidus (Gpi)

Description:

Patients with Dystonia

Treatment:

Procedure: Deep Brain Stimulation

Ventral intermediate nucleus of the thalamus (VIM)

Description:

Patients with Tremor

Treatment:

Procedure: Deep Brain Stimulation