Correlation Research of Thioredoxin Reductase in Lung Cancer (TRCRLC)

Hunan Province Tumor Hospital

Status: Completed

Conditions: Benign Neoplasm of Lung; Non-small Cell Lung Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01985113

TR001

TRRFLC1 (Other Identifier)

Details and patient eligibility

About

In pre-clinical study the investigators found that the thioredoxin reductase activity of serum harbours huge difference between cancer patients and non-cancer patients, the enzyme activity elevated remarkably among cancer patients, so the investigators hypothesis that this is due to tumor cells loading of the patients, the enzyme activity may harbours huge difference between carcinoma tissues and para-carcinoma tissues in early staged non-small cell lung cancers, and after surgery, the enzyme activity may fall down to a normal level because of removing of tumor.

Full description

This is a cooperative research project in Thoracic Surgery Department and Medical Oncology Department of Affiliated Cancer Hospital of xiangya School of Medicine Central South University, and the State Key Laboratory for Natural Medicine and Biomimetic Drugs Perking University. The primary objective is to measure the thioredoxin reductase activity using blood and lung cancer tissue and measure thioredoxin reductase messenger ribonucleic acid (mRNA) and protein expression using lung cancer and pericarcinomatous tissue in early staged(Ⅰ~ⅢA) non-small lung cancers, to study the correlations of thioredoxin reductase between blood and tissue. The secondary objectives are to measure the thioredoxin reductase activity between non small lung cancers and lung benign lesion patients to identify the difference between tumor and lung benign mass.

Enrollment: 165 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pathologically proven staged(Ⅰ~ⅢA) non-small cell lung cancer or CT scan shows resectable lung mass
• Receive surgery in Thoracic Oncology department Hunan Tumor Hospital without contraindication of surgery
• Malignant tumor treatment naive（except for surgery for cervical cancer and cutaneous squamous cell carcinoma 5 years before）
• Signed informed consent about providing blood and tissue for study

Exclusion criteria

• Patients have received antitumor treatment
• Patients with contraindication of surgery or patients who need adjuvant chemotherapy with contraindication of chemotherapy
• Pregnant or breast feeding women

Trial design

165 participants in 2 patient groups

early staged non-small cell lung cancers

Description:

patients who diagnosed as early staged non-small cell lung cancer after surgery

lung benign mass patients

Description:

patients who diagnosed as lung benign mass after surgery