Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Enrolling

Conditions: Intestinal Ischemia; Ultrasonography, Doppler; Critical Illness; Enteral Nutrition Feeding; Hemodynamics

Treatments: Other: enteral nutrition

Study type: Observational

Funder types: Other

Identifiers

NCT07001943

SMART(SMA Reactivity Trial)

Details and patient eligibility

About

This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function. We'll use bedside Doppler ultrasound to monitor superior mesenteric artery (SMA) blood flow changes post - feeding, exploring its correlation with Acute Gastrointestinal Injury (AGI) and other hemodynamic indicators. Our goals are to identify the patterns of SMA blood flow changes, establish a predictive model linking SMA blood flow reactivity to AGI risk, and propose individualized enteral nutrition strategies based on intestinal hemodynamics. Through this innovative approach, we hope to enhance the safety of enteral nutrition, reduce AGI incidence, and improve patient outcomes.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged ≥18 years and ≤80 years.
• Admitted to the study with a expected stay of more than 72 hours.
• Require initiation of enteral nutrition support.

Exclusion criteria

• Pre-existing severe gastrointestinal diseases.
• Patients with gastrointestinal bleeding.
• Patients with bowel obstruction.
• Pregnant or lactating women.
• Patients with contraindications to bedside Doppler ultrasound.