Correlations of the Microvascular Abnormalities on NVC (Nail Fold Video Capillaroscopy) and GAVE (Gastric Antral Vascular Ectasia) as Seen on EGD

Mayo Clinic

Status: Invitation-only

Conditions: Gastric Antral Vascular Ectasia

Treatments: Device: Video Capillaroscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT07127952

25-001900

Details and patient eligibility

About

The purpose of this research is to determine whether a procedure called capillaroscopy can help distinguish patients who are diagnosed with GAVE (gastric antral vascular ectasia) with an autoimmune disease versus idiopathic/other conditions based on EGD findings.

Full description

The primary aim of this study is to define the prevalence and findings (as per quantification) of nail fold video capillaroscopy abnormalities in patients with GAVE. The secondary aim is to compare the findings of NVC and clinical presentation in patients with GAVE.

Enrollment: 75 estimated patients

Sex: All

Ages: 18 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18 years and older with gave diagnosis as pair EGD performed in Gastroenterology as standard of care.

Patients with GAVE with connective tissue disease will be compared to patients with GAVE without a connective tissue disease.

Exclusion criteria

• Age less than 18 years of age, pregnant individuals, dialysis dependent, type 2 diabetes, recent hand trauma or manicure (<2 weeks), routine use of vibratory tools, history of acrocyanosis or erythromelalgia, previous diagnosis of a bleeding disorder, diagnosis of psoriasis, diagnosis of anti-phospholipid syndrome, exposure to toluene or benzoyl, diagnosis of psoriasis, diagnosis of COPD.

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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75 participants in 2 patient groups

GAVE with CTD

Other group

Description:

Will include patients between 18 and 95 years old seen at Mayo Clinic in Florida who were diagnosed with GAVE (Gastric antral vascular ectasia) based on the EGD findings. Will include patients with gave and connective tissue disease. Patient can be identified using slicer dicer or advanced text explorer and will be invited to have a nail fold video capillaroscopy.

Treatment:

Device: Video Capillaroscopy

GAVE without connective tissue disease

Other group

Description:

Will include patients between 18 and 95 seen at Mayo Clinic in Florida who were diagnosed with GAVE based on the EGD findings. Will include patients with GAVE without connective tissue disease Patient can be identified using slicer dicer or advanced text explorer and will be invited to have a nail fold video capillaroscopy.

Treatment:

Device: Video Capillaroscopy