Cortical-Basal Ganglia Speech Networks

Mass General Brigham

Status: Enrolling

Conditions: Essential Tremor; Dystonia; Parkinson Disease

Treatments: Other: electrophysiological data collection

Study type: Interventional

Funder types: Other

Identifiers

NCT04286308

2019P003841

Details and patient eligibility

About

In this research study the researchers want to learn more about brain activity related to speech perception and production.

Full description

Speech production is disrupted in a number of neurological diseases that involve the basal ganglia, including Parkinson's disease (PD) and dystonia. The investigators will use a novel experimental approach and combination of analytic techniques to elucidate the contribution of neural activity in cortical-basal ganglia circuits to the hierarchical control of speech production, in subjects undergoing deep brain stimulation surgery.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Subjects scheduled for DBS implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of Parkinson's disease, essential tremor or dystonia.
2. Subjects able to provide informed consent and comply with task instructions.
3. Subjects 18-85 years old

Exclusion criteria

1. Subjects with reported hearing loss.
2. Non-English-speaking subjects

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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80 participants in 1 patient group

Brain signal data collection

Experimental group

Description:

Brain signal data collection at the time of deep brain stimulation (DBS) surgery.

Treatment:

Other: electrophysiological data collection