Cortical Excitability Assessment Using Paired Pulses (PP)

Civil Hospices of Lyon

Status: Unknown

Conditions: Focal Epilepsy

Treatments: Other: paired pulses cortical electrical stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT02245061

2014.865

2014-A00495-42 (Other Identifier)

Details and patient eligibility

About

The identification of the epileptogenic zone (EZ) during pharmacoresistant focal epilepsy presurgical assessment frequently requires intracranial recordings like stereo-electroencephalography (SEEG). Cortical direct electrical stimulation (DES) is commonly used during SEEG for functional mapping or to induce seizure.

However, the recording of seizures is sometimes insufficient to circumscribe the EZ and development of new biomarkers is necessary.

The cortex within the EZ is thought to be hyperexcitable. The "paired pulses" paradigm, using transcranial magnetic stimulation (TMS), allows determining the hemispheric cortical excitability level. The investigators hypothesize that paired pulses DES during SEEG could provide useful information for EZ identification.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age above 18 years old
• Pharmacoresistant focal epilepsy patients undergoing a stereo-electroencephalographic recording
• Provide written consent to the study after receiving clear information
• Be a beneficiary or member of health insurance plan

Exclusion criteria

Patient with contraindication for MRI scanning

• Pregnancy
• Prohibition on participation in other research, apart from any other non-interventional research

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

paired pulses cortical electrical stimulation

Experimental group

Treatment:

Other: paired pulses cortical electrical stimulation