Cortical Function Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome

Zhengzhou University

Status: Enrolling

Conditions: Lateral Medullary Syndrome; Deglutition Disorders

Treatments: Other: Functional near-infrared spectroscopy (fNIRS) detection

Study type: Observational

Funder types: Other

Identifiers

NCT06208020

LMS dysphagia

Details and patient eligibility

About

The goal of this observational study is to detect the alteration of cortical activation and functional connectivity during swallowing in patients with Lateral Medullary Syndrome (LMS) dysphagia by functional near infrared spectroscopy (fNIRS). The main questions it aims to answer are:

• The alteration of cortical activation during swallowing in patients with LMS compared with healthy subjects.
• The alteration of cortical functional connectivity during swallowing in patients with LMS compared with healthy subjects.

fNIRS will be used to detect cortical activation and functional connectivity during swallowing tasks in LMS patients and healthy subjects, and to compare the differences between patients and healthy subjects.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The first ischemic stroke was confirmed by head MRI as LMS;
• 18-80 years old, right-handed;
• Dysphagia was confirmed by video fluoroscopic swallow study(VFSS);
• Conscious enough to cooperate with fNIRS testing;
• No previous neurological or mental illness.

Exclusion criteria

• Other central nervous system diseases (Parkinson's disease, Alzheimer's disease, intracranial tumors, etc.);
• Other diseases causing dysphagia (tumors of the esophagus, larynx, nasopharynx, etc.);
• Serious physical diseases (cancer, fracture, etc.);
• Other mental disorders (mania, schizophrenia, etc.);
• Unconscious, unable to cooperate with the examination

Trial design

20 participants in 2 patient groups

LMS patients

Description:

The demographic characteristics will be collected, including sex, age, stroke duration, and lesion side; Penetration-aspiration (PAS) scale will be used to evaluate swallowing function. fNIRS will be used to detect changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) during rest and voluntary swallowing.

Treatment:

Other: Functional near-infrared spectroscopy (fNIRS) detection

healthy subjects

Description:

The demographic characteristics will be collected, including sex and age. fNIRS will be used to detect changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) during rest and voluntary swallowing.

Treatment:

Other: Functional near-infrared spectroscopy (fNIRS) detection