Cortical Function Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome

Z

Zhengzhou University

Status

Enrolling

Conditions

Lateral Medullary Syndrome
Deglutition Disorders

Treatments

Other: Functional near-infrared spectroscopy (fNIRS) detection

Study type

Observational

Funder types

Other

Identifiers

NCT06208020
LMS dysphagia

Details and patient eligibility

About

The goal of this observational study is to detect the alteration of cortical activation and functional connectivity during swallowing in patients with Lateral Medullary Syndrome (LMS) dysphagia by functional near infrared spectroscopy (fNIRS). The main questions it aims to answer are: * The alteration of cortical activation during swallowing in patients with LMS compared with healthy subjects. * The alteration of cortical functional connectivity during swallowing in patients with LMS compared with healthy subjects. fNIRS will be used to detect cortical activation and functional connectivity during swallowing tasks in LMS patients and healthy subjects, and to compare the differences between patients and healthy subjects.

Enrollment

20 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • The first ischemic stroke was confirmed by head MRI as LMS;
  • 18-80 years old, right-handed;
  • Dysphagia was confirmed by video fluoroscopic swallow study(VFSS);
  • Conscious enough to cooperate with fNIRS testing;
  • No previous neurological or mental illness.

Exclusion criteria

  • Other central nervous system diseases (Parkinson's disease, Alzheimer's disease, intracranial tumors, etc.);
  • Other diseases causing dysphagia (tumors of the esophagus, larynx, nasopharynx, etc.);
  • Serious physical diseases (cancer, fracture, etc.);
  • Other mental disorders (mania, schizophrenia, etc.);
  • Unconscious, unable to cooperate with the examination

Trial design

20 participants in 2 patient groups

LMS patients
Description:
The demographic characteristics will be collected, including sex, age, stroke duration, and lesion side; Penetration-aspiration (PAS) scale will be used to evaluate swallowing function. fNIRS will be used to detect changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) during rest and voluntary swallowing.
Treatment:
Other: Functional near-infrared spectroscopy (fNIRS) detection
healthy subjects
Description:
The demographic characteristics will be collected, including sex and age. fNIRS will be used to detect changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) during rest and voluntary swallowing.
Treatment:
Other: Functional near-infrared spectroscopy (fNIRS) detection

Trial contacts and locations

1

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Central trial contact

Yi Li, Master

Data sourced from clinicaltrials.gov

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