Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy

The University of Texas System (UT)

Status: Enrolling

Conditions: Spastic Diplegia

Treatments: Procedure: 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT02535936

HSC-MS-15-0335

Details and patient eligibility

About

The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.

Full description

To establish the structural changes in the corticopyramidal tract using diffusion tractography imaging (DTI) due to selective dorsal rhizotomy and compare the resting state functional connectivity(rsfcMRI) temporal latency differences of spastic diplegics for Selective Dorsal Rhizotomy.

Enrollment: 15 estimated patients

Sex: All

Ages: 3 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children diagnosis with Spastic Diplegia and having Selective Dorsal Rhizotomy surgery

Exclusion criteria

• No Selective Dorsal Rhizotomy surgery

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

3Tesla MRI with DTI-MRI and rsfcMRI

Other group

Description:

Patients will receive 2 post-operative MRI's with DTI and rsfcMRI at 2 months and 12 months.

Treatment:

Procedure: 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia