Cortical Representation of Hyperalgesia Induced by Nerve Growth Factor (LOGIN_NGF)

Prof Herta Flor

Status: Completed

Conditions: Healthy Subjects; Non-inflammatory Neuropathic Pain

Treatments: Biological: NGF injection

Study type: Interventional

Funder types: Other

Identifiers

NCT02159170

01ED1010D (Other Grant/Funding Number)

LOGIN_NGF

Details and patient eligibility

About

Intraepidermal injection of nerve growth factor results in a non-inflammatory hyperalgesia for thermal and mechanical stimuli. This hyperalgesia is similar to the pathological ailments of patients with neuropathic pain. The mechanisms of the cognitive modulation of pain and hyperalgesia are not yet understood in this group of patients. The investigators plan to use NGF injection as a model of non-inflammatory neuropathic pain in healthy subjects to investigate the underlying neuronal mechanisms of this hyperalgesia using functional magnetic resonance imaging and resting state network analysis.

Enrollment: 20 patients

Sex: Male

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• no acute or chronic disease
• no acute or chronic pain
• age: 18-60 years
• male
• no medication use

Exclusion criteria

• metallic parts in the body
• claustrophobia
• drug or substance abuse

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

NGF

Experimental group

Description:

injection of 50 µl NGF, once into the left volar forearm and injection of 50 µl NaCl (sodium chloride) once into the right volar forearm

Treatment:

Biological: NGF injection