Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study
Status
Conditions
Details and patient eligibility
About
The aim of the proposed research is to measure the effect of drug-induced sedation on the functional connectivity between brain regions as indicated by EEG signal transmission within the human brain. The results of this study will help to identify the neurophysiological correlates of changes in conscious experience that occur during drug-induced sedation.
Full description
In the proposed experiments cortical areas will be stimulated using low frequency, low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during wakefulness and during drug-induced responsive sedation and unresponsive sedation. Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate the temporal and spatial characteristics of evoked responses and induced rhythms over the cortex.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Healthy right-handed men
- Aged 18-35
- Non-smokers
- No metallic implants
Exclusion criteria
- Younger than 18 or over the age of 35.
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal