Cortico-saving Treatments Proposed for CLIPPERS: a First Cohort

Centre Hospitalier Universitaire de Nīmes

Status: Terminated

Conditions: CLIPPERS

Treatments: Other: Data entry

Study type: Observational

Funder types: Other

Identifiers

NCT01740180

LOCAL/2012/GT

Taieb Cohorte CLIPPERS (Other Identifier)

Details and patient eligibility

About

The primary objective of this study is to collect information about how CLIPPERS patients are currently being treated in France.

Full description

This is an observational study. Data will be prospectively collected, starting with a detailed baseline description of disease and treatment status, followed by updates everything six months for the next three years.

Enrollment: 3 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient correctly informed about the study
• Symptoms and/or clinical signs indicating that the brain stem is affected
• MRI shows punctate gadolinium highlights and/or curvilinear bridge and/or middle cerebellar peduncles
• Clinical and radiological cortico sensitivity
• If a cerebral biopsy has been performed, presence of a lymphocytic, histiocytic or lympho-hysticytic infiltrate

Exclusion criteria

• symptoms and/or clinical signs indicating impairment other than the central nervous system
• Cortical impairment present on MRI, microbleeds, stenosis on magnetic resonance angiography, or pacchymeningitis
• Presence of other diseases that could explain such clinical and radiological signs (see inclusion criteria)
• If a cerebral biopsy has been performed, presence of signs of malignancy (eg, clonal proliferation, cellular atypia), vasculitis, granuloma, or demyelination

Trial design

3 participants in 1 patient group

CLIPPERS patients

Description:

The population concerned by this study consists of patients diagnosed according to CLIPPERS criteria (see inclusion and exclusion criteria). Intervention: Data entry

Treatment:

Other: Data entry