Corticosteroid Injection in Carpal Tunnel Syndrome

Taipei Veterans General Hospital

Status: Completed

Conditions: Carpal Tunnel Syndrome

Treatments: Drug: Triamcinolone Acetonide; Drug: lidocaine hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT03072290

2016-07-006A

Details and patient eligibility

About

To compare the effectiveness of different dose of ultrasound guided steroid injection in patient with carpal tunnel syndrome, by using clinical and electrophysiological parameters in evlauation

Full description

This is a prospective, single-blinded randomized controlled study to determine the efficacy of low dose corticosteroid in patient with CTS. Patient with CTS were randomly assigned to group receiving ultrasound guided steroid injection with different dosage of triamcinolone acetonide (Shincort) mixed, 1ml 10mg (10mg/ml) or 1ml 40mg (40mg/ml) with 1 ml of 2% lidocaine hydrochloride. The follow up at 6 and 12 weeks includes Boston Carpal Tunnel Questionnaire, nerve conductive study and VAS pain score.

Enrollment: 56 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of CTS
• The diagnosis of CTS was confirmed by electrophysiological tests.

Exclusion criteria

• presence of thenar atrophy
• existence of disorders such as hypothyroidism, diabetes mellitus, chronic renal failure, or rheumatoid arthritis; any accompanying orthopedic or neurologic disorders that could mimic CTS such as cervical radiculopathy, polyneuropathy, proximal median nerve entrapment, or thoracic outlet syndrome
• prior steroid injection into the affected carpal tunnel within 6 months or ever received carpal tunnel surgery
• history of distal radius fracture
• pregnancy or lactation
• regular use of systemic NSAIDs ,corticosteroids or diuretics
• known allergy to corticosteroids and local anesthetics.
• impaired cognitive function

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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56 participants in 2 patient groups

low dose steroid

Experimental group

Description:

ultrasound-guided steroid injection using 1ml of 10 mg (10mg/ml) triamcinolone acetonide (Shincort) mixed with 1 ml of 2% lidocaine hydrochloride (Xylocaine)

Treatment:

Drug: lidocaine hydrochloride

Drug: Triamcinolone Acetonide

comparator

Active Comparator group

Description:

ultrasound-guided steroid injection using 1ml of 40 mg (40mg/ml) triamcinolone acetonide (Shincort) mixed with 1 ml of 2% lidocaine hydrochloride (Xylocaine)

Treatment:

Drug: lidocaine hydrochloride

Drug: Triamcinolone Acetonide