Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest

Beth Israel Lahey Health

Status and phase: Completed; Phase 2; Phase 1

Conditions: Cardiac Arrest

Treatments: Drug: Hydrocortisone; Drug: Normal Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT00676585

2007P000227

Details and patient eligibility

About

The major goal of this project is to determine whether the use of physiologic doses of corticosteroids will decrease time to shock reversal, alters the inflammatory cascade, and alters microcirculatory flow in post-cardiac arrest patients.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Greater than 18 years old
• Either pre-hospital cardiac arrest and ROSC or Inpatient Cardiac Arrest with resultant ROSC
• Vasopressor dependent for a minimum of 1 hour post-arrest

Exclusion criteria

• Pregnant
• Indication for Corticosteroids outside of current research proposal
• DNR or comfort care measures
• Presence of septic shock
• Chronic Use (>1week) of oral Corticosteroids in the last year

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups, including a placebo group

2

Placebo Comparator group

Description:

Normal Saline

Treatment:

Drug: Normal Saline

1

Experimental group

Description:

Hydrocortisone 100mg every 8 hours.

Treatment:

Drug: Hydrocortisone