Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Vanderbilt University Medical Center

Status: Enrolling

Conditions: Parkinson Disease

Treatments: Other: Neural stimulation; Other: Neurophysiology recordings

Study type: Interventional

Funder types: Other

Identifiers

NCT04715984

201868

Details and patient eligibility

About

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Enrollment: 75 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
• Planned clinical electrode trajectory that contacts caudate
• Age greater than or equal to 40
• Diagnosis of Parkinson's disease
• Able to participate in intraoperative testing
• English speaking

Exclusion criteria

• Age less than 40
• Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
• Movement disorder other than Parkinson's disease

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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75 participants in 1 patient group

Neural recordings and stimulation

Experimental group

Treatment:

Other: Neurophysiology recordings

Other: Neural stimulation