Cortisol Activity in Patients With Prader-Willi Syndrome and Healthy Controls

Children's Mercy Hospital Kansas City

Status: Completed

Conditions: Prader-Willi Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT00932932

09 01-014

Details and patient eligibility

About

The purpose of the study is to find out if people with Prader-Willi syndrome have a difference in the protein which changes inactive cortisone to the active stress hormone cortisol.

Enrollment: 36 estimated patients

Sex: All

Ages: 6+ months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Prader-Willi syndrome confirmed by molecular testing, ages 6 months to adult
• Controls: Age-matched, sex-matched, developmentally normal, BMI-controlled healthy or obese subjects

Exclusion criteria

• PWS subjects without molecular confirmation of the diagnosis
• Subjects receiving glucocorticoid treatment within 3 months of evaluation
• Subjects receiving growth hormone within one year prior to analysis

Trial design

36 participants in 3 patient groups

PWS not receiving Growth Hormone

Control subjects healthy or obese

PWS subjects starting Growth Hormone