Cortisol Secretion, Sensitivity and Activity and Hypertension (PRECOR)

Istituto Auxologico Italiano

Status

Enrolling

Conditions

Arterial Hypertension

Hypercortisolism

Treatments

Diagnostic Test: Dexamethasone suppression test

Study type

Observational

Funder types

Other

Identifiers

05C921

Details and patient eligibility

About

The goal of this observational study is to evaluate, between patients with arterial hypertension and non hypertensive control group,

the prevalence of hidden hypercortisolism
the relationship between organ damage and oxidative stress level, cortisol secretion degree, sensitivity and peripheral activity

Enrollment

290 estimated patients

Sex

All

Ages

30 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Exclusion criteria

body mass index (BMI) >30 kg/m2
active smoking (>20 cigarettes/day)
pregnancy/lactation
hypertension associated with family history of hypertension and cerebrovascular events before 40 years of age
sleep apnea
hypertension appearance in pre-pubertal age
hypokalemia
hypertension in the setting of an incidental adrenal mass
classic signs and symptoms of hypercortisolism (lunar facies, striae, hypertrichosis, skin atrophy, hump)
proven endocrine hypertension (pheochromocytoma, hyperaldosteronism, hyperparathyroidism, acromegaly, hyperthyroidism)
renovascular hypertension
diseases or conditions associated with increased activity of the hypothalamic-pituitary- adrenal axis and/or oxidative stress, such as type 2 diabetes, rheumatoid arthritis, severe rheumatic/autoimmune diseases, severe hematological diseases, alcoholism, depressive syndrome, chronic renal failure (GFR <45 ml/min), severe hypovitaminosis D (25OHvitaminD <10 ng/dL)
therapies that interfere with the activity of the HPA axis (i.e. glucocorticoids, antidepressants).