Cosmetic Effects of Topical Acetyl Zingerone

University of California (UC) Davis

Status

Completed

Conditions

Lipidome

Erythema

Side Effect

Microbiome

Skin Pigment

Wrinkle Appearance

Treatments

Other: Topical cream

Other: Acetyl Zingerone Topical Cream

Study type

Interventional

Funder types

Other

Identifiers

NCT03530787

1161176

Details and patient eligibility

About

Cosmeceuticals are an emerging market within dermatology and the growth of natural products and derivatives of natural products has accelerated in use within the field. Here the investigators aimed to study the microbial and cosmetic effects of Synoxyl AZ, the trade name for topical acetyl zingerone (AZ), a novel compound designed based on Zingerone and curcumin.

Full description

Cosmeceuticals are an emerging market within dermatology and the growth of natural products and derivatives of natural products has accelerated in use within the field. Here the investigators aim to study Synoxyl AZ, the trade name for topical acetyl zingerone (AZ), a novel compound designed based on Zingerone and curcumin.

Both curcumin and Zingerone are from the Zingiberacea family of plants (also known as the ginger family). Both have been widely studied and noted to have antibacterial effects and promote skin health effects. Curcumin has been studied widely in recent years due to various microbial effects. AZ is a derivative that is similar to both Zingerone and curcumin and has been noted to have many different activities including anti-inflammatory, antimicrobial, and antioxidant functions. However, there are no studies looking at how it modulates the skin cosmetically or the superficial microbiome.

The aim of this study was to compare the cosmetic effects of AZ to a vehicle over an 8-week period.

Enrollment

31 patients

Sex

All

Ages

30 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Individuals aged 30-60
Healthy subjects

Exclusion criteria

Those that have had topical antibiotics within the past 4 weeks
Those that have had oral antibiotics within past 4 weeks
Those who have used systemic isotretinoin in the last 6 months
Those with a known allergy to members of the ginger family
Current smokers OR 20 pack-year history of smoking OR Have smoked within the past 3 years
Pregnant women
Prisoners
Those who have had any change to their hormonal birth control regimen in the last 4 weeks.
Those with visible signs in the area of application of or on active treatment for cystic acne, eczema, seborrheic dermatitis, papulopustular rosacea at investigator discretion
Those who have had a recent surgical or cosmetic procedure in the last 3 months that can affect facial wrinkles or facial hyperpigmentation, such as botulinum toxin injections, chemical peels, laser based therapies to the face, or face lift surgeries at investigator discretion