Costimulatory Molecules as Biomarkers in Cystic Fibrosis

Oregon Health & Science University (OHSU)

Status: Completed

Conditions: Cystic Fibrosis

Study type: Observational

Funder types: Other

Identifiers

NCT01353950

IRB00007132

Details and patient eligibility

About

The purpose of this study is to investigate the expression of a certain class of molecules, called costimulatory molecules, in humans with Cystic Fibrosis. Cystic Fibrosis is a genetic disorder which renders the lung susceptible to persistent inflammation which, at times, can worsen, resulting in accelerated decline in lung function and eventually death or transplant. Our goal is to determine if the levels of costimulatory markers can be used to predict exacerbation and subsequent lung function decline in subjects with Cystic Fibrosis.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Willingness to participate

Exclusion criteria

• Presence of HIV
• Presence of Lymphoma/Leukemia
• Presence of Lung or other solid organ Transplant
• Pregnancy

Trial design

40 participants in 1 patient group

Adult Cystic Fibrosis Patients

Description:

Adults with Cystic Fibrosis will be followed longitudinally for 2 years