Cotinus Coggygria Mouthwash and Halitosis and Oral Hygiene in Orthodontic Patients

National and Kapodistrian University of Athens

Status: Completed

Conditions: Halitosis; Orthodontic Appliance Complication

Treatments: Dietary Supplement: Cotinus Coggygria mouthwash; Dietary Supplement: Placebo mouthwash

Study type: Interventional

Funder types: Other

Identifiers

NCT07254819

680/03.02.2025

Details and patient eligibility

About

The aim of this trial was to investigate the effect of Cotinus Coggygria mouthwash on halitosis using as proxy the levels of the Volatile Sulfur Compounds (VSCs), and the effect on plaque and gingival indices in adolescents undergoing orthodontic treatment with fixed conventional labial appliances.

Enrollment: 30 patients

Sex: All

Ages: 13 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients eligible for the trial must comply with all of the following at randomization:

• Age between 13 and 18 years for the group with conventional orthodontic appliances.

This age group represents the majority of patients seeking orthodontic treatment and is homogeneous regarding occupational status (high-school and lyceum students in Greece). Younger patients might present with cooperation problems.

• Good general health.
• Orthodontic fixed labial appliances on the maxillary and mandibular arch, brackets at least on 20 teeth for more than 4 months before enrollment and estimated duration of the treatment more than 1 month, bands on the first molars, extraction cases patients could be enrolled at least two months after the last extraction.
• Total initial VSCs levels above the baseline level of 150ppb.

Exclusion criteria

Patients will be excluded for any of the following reasons:

• Active caries
• Periodontitis
• Dental fluorosis / dysplasia of the teeth
• Syndromes, mental disabilities and craniofacial deformities
• Smoking or use of other tobacco products
• Allergy to Cotinus Coggygria (Smoke tree)
• Antibiotics during the last 2 months
• Chlorhexidine or other mouthwash use in the previous 3 weeks
• Participation in other trials

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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30 participants in 2 patient groups, including a placebo group

Experimental: Experimental group Cotinus Coggygria mouthwash

Experimental group

Description:

Experimental Group: patients, age 13-18, conventional brackets, Cotinus Coggygria mouthwash 15 patients, with conventional brackets

Treatment:

Dietary Supplement: Cotinus Coggygria mouthwash

Placebo control arm: placebo mouthwash

Placebo Comparator group

Description:

Control Group: patients, age 13-18, conventional brackets, Placebo mouthwash 15 patients, with conventional brackets

Treatment:

Dietary Supplement: Placebo mouthwash