Cough in Eastern and Central Finland

Kuopio University Hospital

Status: Completed

Conditions: Chronic Cough

Treatments: Diagnostic Test: Mannitol aerosol bronchial challenge; Diagnostic Test: Citric acid aerosol bronchial challenge

Study type: Interventional

Funder types: Other

Identifiers

NCT03639727

KUH5801136

Details and patient eligibility

About

Comparison of citric acid and mannitol cough provocation tests among subjects with chronic cough and healthy volunteers.

Full description

35 subjects with chronic cough plus 25 subjects without any cough will be asked to participate. The study consists of two visits in the outpatient clinic of Kuopio University Hospital, department of respiratory medicine, 2 - 7 days apart. They will fill in the Leicester Cough Questionnaire and undergo two different cough provocation tests, in random order: Mannitol test and citric acid test. If a chest x-ray has not been taken within 6 months, it will be taken.

Enrollment: 61 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria, Chronic cough patients:

(both criteria must be fulfilled)

• presence of current chronic cough (> 8 weeks)
• Leicester Cough Questionnaire total score < 17

Inclusion criteria, healthy volunteers

• absence of any form of cough

Exclusion Criteria:

• age < 18 years
• any disability which would challenge the subject's ability to understand the purpose and methods of the study
• pregnancy
• breastfeeding
• current smoking or ex smoking more than 10 pack years
• any thoracic x-ray finding indicating urgent mediacal interventions

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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61 participants in 2 patient groups

Citric acid aerosol bronchial challenge

Active Comparator group

Description:

Inhaled citric acid aerosol. This study investigates the diagnostic accuracy of two cough provocation tests, one of which is citric acid aerosol challenge.

Treatment:

Diagnostic Test: Citric acid aerosol bronchial challenge

Mannitol aerosol bronchial challenge

Active Comparator group

Description:

Inhaled mannitol aerosol. This study investigates the diagnostic accuracy of two cough provocation tests, one of which is mannitol aerosol challenge.

Treatment:

Diagnostic Test: Mannitol aerosol bronchial challenge