Could Apnea Induce Hypoalgesia?

Centro Universitario La Salle

Status

Completed

Conditions

Apnea

Pain

Treatments

Other: Apnea

Other: Control Intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT05991141

CSEULS-PI-029/2022

Details and patient eligibility

About

A randomized controlled trial (RCT) in healthy subjects will be conducted with the following aims: (1) Explore the effect of low pulmonary volume dynamic apnoea bouts on Pressure Pain Threshold (PPT) and conditioned pain modulation (CPM); (2) analyse whether CPM response correlates with apnoea induced hypoalgesia; (3) examine the association between apnoea bouts, Rate of Perceived Exertion, hypoxemia and Heart Rate changes in PPT.

Full description

A randomized controlled trial (RCT) in healthy subjects will be conducted with the following aims: (1) Explore the effect of low pulmonary volume dynamic apnoea bouts on Pressure Pain Threshold (PPT) and conditioned pain modulation (CPM); (2) analyse whether CPM response correlates with apnoea induced hypoalgesia; (3) examine the association between apnoea bouts Rate of Perceived Exertion, hypoxemia and Heart Rate changes in PPT

Enrollment

30 patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy participants
18-30 years
Currently pain-free
Basal SpO2 ≥95%

Exclusion criteria

Diabetes diagnosis
Hypertension or hypotension diagnosis
Pharmacological treatment
Frequent pain during last month
Drug consumption
Self-harming behaviours
Pregnant or potentially pregnant
Cardiac or respiratory pathology
Splenectomy or spleen disease
Having performed moderate or high intensity physical activity 24 hours prior to the study
Not having slept the previous night
Alcohol intake 24 hours prior to study.