Could Non-invasive Biochemical, Image or Physiological Index Predict Significant Coronary Arterial Stenosis in Symptomatic Adults?

Cathay General Hospital

Status: Unknown

Conditions: Coronary Heart Disease

Treatments: Radiation: coronary calcium score measurement; Biological: high sensitivity C reactive protein measurement; Procedure: ankle brachial index measurement

Study type: Observational

Funder types: Other

Identifiers

NCT01645228

NSC 101-2314-B-281 -007 (Other Grant/Funding Number)

CGH-P100133

Details and patient eligibility

About

To validate the capability of non-invasive bio-image tests in prediction of significant coronary stenosis of symptomatic adults.

Full description

The main objective is to validate the capability of these non-invasive tests (CCS, hs-CRP and ABI) in prediction of significant coronary stenosis of symptomatic adults. The end-point will be the findings of coronary CT angiography. The investigators hope the results of our study could be applied on the interpretation of health examination and the advice of follow-up and therapy.

Enrollment: 120 estimated patients

Sex: All

Ages: 30+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• subjects for a general health check-up protocol, which included CACS and CCTA, and biochemical measurements (total cholesterol, total triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, high sensitivity C reactive protein)

Exclusion criteria

• anyone allergy to iodine contrast medium, unable cooperation for CT scanning, asymptomatic

Trial design

120 participants in 1 patient group

significant coronary artery stenosis

Description:

anyone coronary segment \> 50% diameter stenosis

Treatment:

Radiation: coronary calcium score measurement

Procedure: ankle brachial index measurement

Biological: high sensitivity C reactive protein measurement