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Covert-saccades, Dynamic Visual Acuity and Quality of Life (COSQOL)

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Civil Hospices of Lyon

Status

Completed

Conditions

Vestibular Diseases

Treatments

Other: Dizziness Handicap Inventory
Other: VEMPs & VEMPo
Other: Oscillopsia severity questionnaire
Other: Head Impulse Tests
Other: Dynamic visual acuity Test (DVAT)

Study type

Interventional

Funder types

Other

Identifiers

NCT02753179
69HCL15_0746

Details and patient eligibility

About

Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The objective of this study is to evaluate the potential functional benefice of these compensatory movements in a population of 20 patients with chronic bilateral areflexia, in a cross-sectional study.

Enrollment

20 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Bilateral Vestibular Hypofunction (BVH) with at least two of the tree following criteria

    • Mean peak slow phase velocity of 5°/s or less in bilateral bithermal (30 and 44°C) caloric irrigations
    • Pathologic Head-impulse test
    • VOR gain of <0.25 on rotatory chair tests
  • Disorder present for over 6 month

  • Comprehension of the experiments instructions

  • Patient consent

Exclusion criteria

  • Corrected Visual Acuity lower than 5/10
  • Other conditions leading to oscillopsia or ataxia
  • Oculomotor palsy, ocular instability in primary position
  • Cervical rachis pathology with instability
  • Cochlear Implants
  • Non-stabilized medical disease
  • Pregnant women
  • Patients under tutelage

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

20 participants in 1 patient group

Bilateral vestibular hypofunction
Experimental group
Description:
Patients suffering from chronic bilateral vestibular hypofunction.
Treatment:
Other: Dynamic visual acuity Test (DVAT)
Other: Head Impulse Tests
Other: Oscillopsia severity questionnaire
Other: Dizziness Handicap Inventory
Other: VEMPs & VEMPo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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