Covert-saccades, Dynamic Visual Acuity and Quality of Life (COSQOL)

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Civil Hospices of Lyon

Status

Completed

Conditions

Vestibular Diseases

Treatments

Other: Dizziness Handicap Inventory
Other: VEMPs & VEMPo
Other: Dynamic visual acuity Test (DVAT)
Other: Oscillopsia severity questionnaire
Other: Head Impulse Tests

Study type

Interventional

Funder types

Other

Identifiers

NCT02753179
69HCL15_0746

Details and patient eligibility

About

Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The objective of this study is to evaluate the potential functional benefice of these compensatory movements in a population of 20 patients with chronic bilateral areflexia, in a cross-sectional study.

Enrollment

20 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Bilateral Vestibular Hypofunction (BVH) with at least two of the tree following criteria

  • Mean peak slow phase velocity of 5°/s or less in bilateral bithermal (30 and 44°C) caloric irrigations
  • Pathologic Head-impulse test
  • VOR gain of <0.25 on rotatory chair tests
  • Disorder present for over 6 month
  • Comprehension of the experiments instructions
  • Patient consent

Exclusion criteria

  • Corrected Visual Acuity lower than 5/10
  • Other conditions leading to oscillopsia or ataxia
  • Oculomotor palsy, ocular instability in primary position
  • Cervical rachis pathology with instability
  • Cochlear Implants
  • Non-stabilized medical disease
  • Pregnant women
  • Patients under tutelage

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

20 participants in 1 patient group

Bilateral vestibular hypofunction
Experimental group
Description:
Patients suffering from chronic bilateral vestibular hypofunction.
Treatment:
Other: Head Impulse Tests
Other: Oscillopsia severity questionnaire
Other: Dynamic visual acuity Test (DVAT)
Other: VEMPs & VEMPo
Other: Dizziness Handicap Inventory

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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