COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic (CoVAPid2)

University Hospital, Lille

Status: Unknown

Conditions: Severe COVID-19

Study type: Observational

Funder types: Other

Identifiers

NCT05256511

HLJ_2022_01

Details and patient eligibility

About

Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.

Full description

CoVAPid2 is a multicenter retrospective observational cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic. Patients with confirmed SARS-CoV-2 community-acquired pneumonia and receiving invasive mechanical ventilation for more than 48h in the participating ICUs from the start of COVID pandemic are eligible for this study. Consecutive patients will be included from the beginning of the first wave (starting on 01-01-2020, data already collected in the CoVAPid1 study) and the second wave (starting on 10-01-2020). 10-20 patients per wave will be included in each center. VAT and VAP are defined using clinical, radiological and quantitative microbiological criteria.

Enrollment: 1,136 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major (18 years and older)
• Admitted to the ICU
• Intubated and mechanically ventilated for more than 48 hours
• With a confirmed community-acquired SARS-CoV2 pneumonia

Exclusion criteria

• Refusal to participate
• Lack of social security coverage

Trial design

1,136 participants in 2 patient groups

SARS-CoV-2 first wave

Description:

Patients with confirmed SARS-CoV-2 infection and receiving invasive mechanical ventilation for more than 48h, in the first wave of the pandemic, starting on 01-01-2020

SARS-CoV-2 second wave

Description:

Patients with confirmed SARS-CoV-2 infection and receiving invasive mechanical ventilation for more than 48h, in the second wave of the pandemic, starting on 10-01-2020