COVid-19: Awake Proning and High-flow Nasal Cannula in respiratorY DistrEss (COVAYDE)

Hôpital de Verdun

Status

Completed

Conditions

Respiratory Distress Syndrome

Respiratory Failure

Lung Diseases

Respiratory Insufficiency

COVID

Severe Acute Respiratory Syndrome

ARDS

Coronavirus Infection

Treatments

Procedure: Standard care

Procedure: Awake Prone Positioning

Study type

Interventional

Funder types

Other

Identifiers

NCT04395144

2021-01

Details and patient eligibility

About

Prone positioning is an established intervention in mechanically ventilated acute respiratory distress syndrome (ARDS) patients, with demonstrated reductions in mortality.

Preliminary data suggest that awake proning in patients with COVID-19 treated with high-flow nasal oxygenation (HFNO) improves gas exchanges, and might be associated with a reduced need of mechanical ventilation, and reduced mortality. Further investigation in a formal randomized-controlled trial is need.

Enrollment

13 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

COVID-19, either confirmed by SARS-CoV-2 assay, or clinically suspected, with results of the assay pending;
Lung infiltrates documented on chest X-ray or chest CT-scan;
Significant respiratory distress that requires treatment with HFNO.

Exclusion criteria

Unable to consent;
Unable to prone;
Indication for immediate endotracheal intubation and mechanical ventilation;
Contraindication to prone positioning (severe obesity, abdominal wound, pregnancy, unstable pelvic/spinal lesions, vomiting, etc.);
Comfort care or imminent expectation of death.