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COVID-19 Genomic Sequencing for Nosocomial Outbreak Investigations (NOSO-COVID)

C

Centre hospitalier de l'Université de Montréal (CHUM)

Status

Completed

Conditions

Molecular Sequence Variation
COVID-19
Nosocomial Infection

Treatments

Diagnostic Test: SARS-CoV-2 genomic sequencing

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

This is a tertiary care hospital-based prospective molecular epidemiology study in Montreal, Canada. When nosocomial transmission was suspected by local infection control teams' investigations, SARS-CoV-2 viral genomic sequencing was performed locally for all putative outbreak cases and contemporary controls. Molecular and conventional epidemiology data were confronted in real time to improve understanding of COVID-19 transmission and reinforce or adapt prevention measures.

Full description

This study will include infected healthcare workers (HCW) and patients for whom a nosocomial infection in CHUM is suspected. The CHUM laboratory is responsible for COVID-19 diagnostic testing in all eligible HCW and patients. After initial diagnosis on standard PCR testing, samples are maintained at -80. Viral RNA is extracted and next-generation sequencing of the viral genome is performed using Nanopore long read sequencing platform. Preliminary data suggest that SARS-CoV-2 has a "molecular clock" of 2 single nucleotide polymorphism (SNP) per month. The analysis and between-isolate comparaison of those SNP among epidemiologically related cases will allow to support or refute the hypothesis of person to person nosocomial transmission. All infected patients will be matched 1:1 with contemporary community cases to provide a viral genome back catalog and better contextualize molecular epidemiology analyses. Molecular clusters will be reported to infection prevention and control teams and resulting interventions will be monitored.

Enrollment

150 patients

Sex

All

Ages

18 to 100 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Hospitalized in the institution during the study period
  • Healthcare workers in the institution during the study period

Exclusion criteria

  • None

Trial contacts and locations

1

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Central trial contact

Floriane Point, Msc; Simon Grandjean Lapierre, MD MSc FRCPC

Data sourced from clinicaltrials.gov

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