COVID-19: Herd Immunity Study in the Czech Republic (SARSCoV2CZPrev)

Institute of Health Information and Statistics of the Czech Republic

Status: Completed

Conditions: SARS-CoV 2; COVID

Treatments: Diagnostic Test: SARS-CoV-2 diagnostic rapid test; Diagnostic Test: Quantitative analysis of SARS-CoV-2 antibodies

Study type: Observational

Funder types: Other

Identifiers

NCT04401085

UZIS 2020/1

Details and patient eligibility

About

The aim of the SARS-CoV-2-CZ-Preval study is to quantify the prevalence of individuals with a history of SARS-CoV-2 coronavirus infection in the Czech population, except for those diagnosed with COVID-19 by methods based on direct detection of SARS-CoV- 2, including individuals with a subclinical course of the disease.

Full description

COVID-19 is caused by a new type of coronavirus called SARS-CoV-2. It is a highly infectious disease, manifested mainly by fever, respiratory problems, muscle pain, and fatigue. However, despite the publication of hundreds of papers in the literature, fundamental information about the spread and course of the disease is still lacking in COVID-19. One of such key pieces of information is the prevalence of asymptomatic individuals with SARS-CoV-2 infection, which has a significant effect on the dynamics of the spread of COVID-19 in the Czech Republic and within individual regions and localities.

The SARS-CoV-2-CZ-Preval study is aiming at quantification of the prevalence of individuals with a history of SARS-CoV-2 coronavirus infection in the Czech population, except for those diagnosed with COVID-19 by methods based on direct detection of SARS-CoV- 2, including individuals with a subclinical course of the disease.

Enrollment: 27,000 patients

Sex: All

Ages: 8 to 89 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• signed Informed Consent
• residing in The Czech Republic
• demographic criteria: (i) persons aged 8-17 (specific children's cohort), (ii) persons aged 18-89
• clinical criteria: (i) without acute health problems (ii) without a confirmed diagnosis of COVID-19
• geographic criteria: according to a particular cohort definition

Trial design

27,000 participants in 3 patient groups

Population area cohort - Control Cohort

Description:

A population cohort of asymptomatic individuals (only adults). This is a representative sample of the population, which are part of the research project of Institute for Clinical and Experimental Medicine and Czech Academy of Sciences. The second subsample included individuals from the official household survey of Czech Statistical Office. This cohort allowed better comparative analysis of other population cohorts from specific geographical areas.

Treatment:

Diagnostic Test: SARS-CoV-2 diagnostic rapid test

Population cohort from specific geographical areas

Description:

This cohort is based on epidemiologically defined demographic parameters. These are populations from the following geographical areas: Brno and the South Moravian Region; Praha; Olomouc; Litoměřice; Litovel and Uničov.

Treatment:

Diagnostic Test: SARS-CoV-2 diagnostic rapid test

Diagnostic Test: Quantitative analysis of SARS-CoV-2 antibodies

Chronically ill patients cohort

Description:

A cohort of chronically ill people enrolled by Institute for Clinical and Experimental Medicine with chronic cardiovascular problems, hypertension, or diabetes.

Treatment:

Diagnostic Test: SARS-CoV-2 diagnostic rapid test