COVID-19 in Hospitalised Norwegian Children - Risk Factors, Outcomes and Immunology

University Hospital, Akershus

Status

Enrolling

Conditions

Fatigue Post Viral

COVID

Pediatric Respiratory Diseases

Study type

Observational

Funder types

Other

Identifiers

NCT04335773

20/03794

Details and patient eligibility

About

Prospective cohort study of COVID-19 infection among children in Norway.

Full description

This nation-wide, prospective cohort study of COVID-19 infection addresses three main issues: 1) Epidemiological risk factors; 2) Natural history (including immunological mechanisms and long term effects) and 3) Support of infection prevention. Also, the study focuses solely on children.

Children (0-18 years of age) admitted to hospital with suspected COVID-19 are eligible (Fig. 1). Those with confirmed COVID-19 serve as cases, whereas those with non-COVID-19 serve as controls; both groups will be followed prospectively for 6 months. Three objectives/Work Packages (WPs) are defined:

In WP1, the investigators will investigate risk factors for severe outcome of the acute infection; potential risk factors include sex, age, comorbidities, initial clinical findings, infectious load, and genetic markers.
In WP2, the investigators will investigate the immunological response to acute infection, focusing on initial innate host response and its associations to inflammatory enhancement, genetic factors and clinical course.
In WP3, the investigators will investigate the prevalence and risk factors of long-lasting complication, in particular the development of post-infectious chronic fatigue

Enrollment

350 estimated patients

Sex

All

Ages

Under 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Suspected covid-19 infection and age 0-18 years

Exclusion criteria

Age >18 years