COVID-19 Infection and Epithelial Cell Markers

McMaster University

Status: Unknown

Conditions: Asthma; Covid19

Study type: Observational

Funder types: Other

Identifiers

NCT04787588

11033-T

Details and patient eligibility

About

To assess if TSLP expression by airway epithelial cells following COVID-19 infection regulates viral load and disease severity.

Full description

The study aim is to determine the relationship between COVID-19 infection and epithelial cell expression of TSLP. Two cohorts will be used. Cohort One will include 100 hospitalized patients with Covid-19, and 100 hospitalized patients without Covid-19. Cohort 2 will include mild/moderate asthmatics and healthy controls with bio-banked biopsy material used from donors who have previously consented for samples to be used for future research.

Enrollment: 235 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 years and above;
• Able to give informed consent;
• Clinically tested for SARS-CoV-2 (as completed by standard laboratory testing e.g. RT-PCR) and with a positive result and clinical features in keeping with COVID-19 illness. The control group will be patients with a negative RT-PCR COVID-19 test and without any clinical features to suggest COVID-19 illness. In addition, the control group should have NO known or current features of respiratory infection, COPD, asthma, interstitial lung disease, other respiratory inflammatory conditions or lung cancer.
• Able to provide a breath sample (as based on clinical judgement).

Exclusion criteria

• none

Trial design

235 participants in 2 patient groups

Hospitalized patients

Description:

100 patients hospitalized with Covid-19, and 100 hospitalized controls without Covid-19

Mild/Moderate asthma and health controls

Description:

20 asthmatic patients, 10 patients with asthma and allergic rhinitis, and 5 healthy controls.