COVID-19 on Disease Activity in Radiologically Isolated Syndrome Cohort (VaxiRIS)

Centre Hospitalier Universitaire de Nice

Status: Completed

Conditions: COVID-19; Multiple Sclerosis

Treatments: Other: NO intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05387395

22Neuro02

Details and patient eligibility

About

The Radiologically Isolated Syndrome (RIS) is defined as incidental Magnetic Resonance Imaging (MRI) abnormalities fulfil the criteria for dissemination in space, suggestive of multiple sclerosis. Nowadays, mandatory vaccination in patients with multiple sclerosis (MS) is widely recommended. Regarding COVID19, the absence of specific warnings led to the proposal of vaccination in patients with inflammatory diseases of the central nervous system. We aimed to evaluate if COVID19 vaccination or infection increased the risk of clinical conversion to multiple sclerosis or evidence of disease activity (EDA) in a cohort of RIS subjects.

Enrollment: 217 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients belong to the RISC cohort;
• totally vaccinated ou partially vaccinated patient
• vaccination status known

Exclusion criteria

• presented a first clinical event before the COVID19 vaccination

Trial design

217 participants in 2 patient groups

complete vaccination

Description:

Complete vaccination was defined as administering two doses of mRNA or AstraZeneca vaccine, administration of one dose of Jansen vaccine, or administration of one dose of any vaccine in patients with a history of COVID19 infection.

Treatment:

Other: NO intervention

incomplete vaccination

Description:

Other cases were defined as incomplete or absent vaccination.

Treatment:

Other: NO intervention