COVID-19 Related Lung Ventilation and Perfusion Injury

McMaster University

Status: Completed

Conditions: Healthy; Asthma; Covid-19

Treatments: Other: St. George's Respiratory Questionnaire (SGRQ); Other: Spirometry; Other: Six-minute walk test (6MWT); Other: mMRC (Modified Medical Research Council) Dyspnea Scale; Other: Plethysmography & DLCO; Other: V/Q SPECT-CT; Other: Airwave Oscillometry

Study type: Observational

Funder types: Other

Identifiers

NCT04549636

FIRH002

Details and patient eligibility

About

Little is currently known about the immediate and long-term effect of COVID-19 on lung ventilation (delivery of air to the lungs) and lung perfusion (delivery of blood to the lungs). Some people who survive COVID-19 may have lung ventilation and/or perfusion injury that persists following COVID-19 recovery. This lung injury may be related to inflammation in the lung, breathlessness, exercise limitation and reduced quality of life. Therefore, towards the goal of understanding the effects of COVID-19 on lung health, the purpose of this study is to characterize and understand the clinical relevance of COVID-19 related lung ventilation and perfusion injury and associated inflammatory status, ≤4 weeks and 6-months following COVID-19 recovery in an asthmatic and healthy population. To do this, an asthmatic and healthy population who have, and have not, been previously diagnosed with COVID-19 will be studied.

Enrollment: 42 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

For all participants:

• Males and females ≥ 18 years of age
• Individuals able and willing to provide written informed consent
• Individuals able and willing to comply with the study protocol

For participants with asthma:

• Individuals with physician confirmed asthma (12% bronchodilator reversibility or PC20 methacholine less than 8mg/ml)
• Individuals treated with inhaled corticosteroids, oral corticosteroids and/or anti-T2 biologics

For participants who recently recovered from covid-19:

• Individuals previously diagnosed with covid-19 confirmed by FLOQswab test
• Individuals who recently (≤4-weeks) recovered from covid-19

Exclusion criteria

For all participants:

• Males and females < 18 years of age
• Individuals who are unable to read and/or understand English
• Individuals who are pregnant or breastfeeding
• Individuals who currently smoke or are an ex-smoker with ≥10 pack-year smoking history
• Individuals who in the opinion of the investigator, are mentally or legally incapacitated, preventing informed consent from being obtained
• Individuals who are unable to complete one or more study manoeuvres

For participants with no history of lung disease:

• Individuals with a history of respiratory infection or disease

For participants who have not been diagnosed with covid-19:

• Individuals who have previously had covid-19 confirmed by FLOQswab test

Trial design

42 participants in 4 patient groups

healthy COVID-19+

Description:

Individuals who recently recovered from COVID-19 and who have no history of lung disease

Treatment:

Other: Airwave Oscillometry

Other: V/Q SPECT-CT

Other: Plethysmography & DLCO

Other: mMRC (Modified Medical Research Council) Dyspnea Scale

Other: Spirometry

Other: Six-minute walk test (6MWT)

Other: St. George's Respiratory Questionnaire (SGRQ)

asthmatic COVID-19+

Description:

Individuals who recently recovered from COVID-19 and who have asthma

Treatment:

Other: Airwave Oscillometry

Other: V/Q SPECT-CT

Other: Plethysmography & DLCO

Other: mMRC (Modified Medical Research Council) Dyspnea Scale

Other: Spirometry

Other: Six-minute walk test (6MWT)

Other: St. George's Respiratory Questionnaire (SGRQ)

healthy COVID-19-

Description:

Individuals who have not been diagnosed with COVID-19 and who have no history of lung disease

Treatment:

Other: Airwave Oscillometry

Other: V/Q SPECT-CT

Other: Plethysmography & DLCO

Other: mMRC (Modified Medical Research Council) Dyspnea Scale

Other: Spirometry

Other: Six-minute walk test (6MWT)

Other: St. George's Respiratory Questionnaire (SGRQ)

asthmatic COVID-19-

Description:

Individuals who have not been diagnosed with COVID-19 and who have asthma

Treatment:

Other: Airwave Oscillometry

Other: V/Q SPECT-CT

Other: Plethysmography & DLCO

Other: mMRC (Modified Medical Research Council) Dyspnea Scale

Other: Spirometry

Other: Six-minute walk test (6MWT)

Other: St. George's Respiratory Questionnaire (SGRQ)