COVID-19 Serology and Immunosenescence (SERO-CoV-OLD)

Centre Hospitalier Universitaire, Amiens

Status

Active, not recruiting

Conditions

Covid19

Immunosenescence

Seroconversion

Geriatric Medicine

Treatments

Biological: blood sample

Study type

Interventional

Funder types

Other

Identifiers

NCT04563650

PI2020_843_0079

Details and patient eligibility

About

This study aims to determine how long COVID-19 neutralizing antibodies can be detected in an elderly institutionalized population presenting fragility factors.

This study also aims to stratify seroconversion by immunological profiles of the elderly patients residing in the EHPAD. This stratification requires the measurement of immunological marker levels already described in immunosenescence and also involved in the development of certain chronic infectious diseases more common in the elderly population. This analysis will enable the investigators to describe an immunological, clinical and biological profile representing a patient who has developed an immunity against COVID 19. It will also help the investigators to understand the different mechanisms leading to a reduced immune response after a potential administration of a vaccine. Finally, it will help describe the immune profiles of elderly residents who presented with non-severe forms of COVID-19.

Enrollment

98 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Residents of the EHPAD/USLD St Victor of the Amiens CHU who took part in the screening campaign (RT-PCR and serology) organized by the Amiens CHU
residents who signed a consent form to participate in the study

Exclusion criteria