COVID-19 Vaccine Reactogenicity and Immunogenicity

Korea University

Status: Unknown

Conditions: COVID-19; Vaccine Adverse Reaction; Vaccine Immune Response

Treatments: Biological: mRNA-1273 COVID-19 vaccine

Study type: Observational

Funder types: Other

Identifiers

NCT05258708

2021GR0274

Details and patient eligibility

About

Analysis of antibody kinetics after vaccination with mRNA-1273 and factors influencing the vaccine immunogenicity

Full description

We conducted a prospective study on healthy young adults who were to receive two doses of mRNA-1273 vaccine at 28-day intervals. After each dose, adverse events were prospectively evaluated, and blood samples were collected. The correlation between humoral immune response and reactogenicity after vaccination was determined. In addition, long-term anti-SARS-CoV-2 antibody kinetics will be assessed.

Enrollment: 179 estimated patients

Sex: All

Ages: 19 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• who were willing to receive the mRNA-1273 vaccine

Exclusion criteria

• previously diagnosed with laboratory-confirmed COVID-19
• history of autoimmune disease
• immunocompromised, pregnant, or breastfeeding