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We have reported that CPAP treatment improved the walking capacity of overlap syndrome patients.
However, the previous study was not randomized, double blinded study. Therefore, we design a prospective, randomized, double blinded, controlled, cross-over trial to confirm this finding.
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inclusion criteria :
exclusion criteria :
primary outcome : exercise capacity (walking distance (meter), measured by incremental shuttle walking test)
Method : For those fit in criteria. CPAP titration will be performed to determine the optimal pressure Baseline measurement : incremental shuttle walking test, urine catecholamine, heart rate variability, muscle power and other baseline characteristics Randomized those patients to group A and group B group A : CPAP treatment with optimal pressure for 1 month, repeat measurement change CPAP treatment to sham pressure 5cm H2O for 1 month, repeat measurement group B : CPAP treatment with sham pressure for 1 month, repeat measurement change CPAP treatment with optimal pressure for 1 month, repeat measurement
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60 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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