CPI-613 Given With Metformin in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Wake Forest University (WFU)

Status and phase: Withdrawn; Phase 2

Conditions: Acute Myeloid Leukemia Refractory; Acute Myeloid Leukemia, in Relapse; Granulocytic Sarcoma

Treatments: Biological: Blood draws; Procedure: Bone marrow biopsy; Drug: CPI 613; Drug: Metformin

Study type: Interventional

Funder types: Other; Industry; NIH

Identifiers

NCT05854966

P30CA012197 (U.S. NIH Grant/Contract)

WFBCCC 22323

Details and patient eligibility

About

The purpose of this research study is to find out what effects (the good and bad) the combination treatment of metformin and CPI-613 has in treating participants with acute myeloid leukemia or granulocytic sarcoma that has either returned after treatment or did not respond to treatment.

Full description

Primary Objective: To establish the feasibility of delivering the combination of CPI-613 and metformin in patients with relapsed or refractory acute myeloid leukemia (AML).

Secondary Objectives: To determine the response rate of CPI-613 and metformin in relapsed or refractory AML defined as Complete remission (CR) + Complete remission with incomplete count recovery (CRi) + Morphologic Leukemia-Free State (MLFS).

• To determine the overall survival of patients with relapsed or refractory AML treated with CPI-613 and metformin.
• To determine the safety of CPI-613 and metformin in patients with relapsed or refractory acute myeloid leukemia (AML).

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients must have histologically or cytologically documented relapsed and/or refractory Acute Myeloid Leukemia or granulocytic sarcoma.
• Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 3.
• Must be ≥ 18 years of age.
• Persons of child-bearing potential (i.e., women who are pre-menopausal or not surgically sterile) must use accepted contraceptive methods (abstinence, intrauterine device [IUD], oral contraceptive or double barrier device), and must have a negative serum or urine pregnancy test within 1 week prior to treatment initiation.
• Persons who are having sexual relationships in which their partner may become pregnant must practice effective contraceptive methods during the study treatment and for 60 days after the last dose of study treatment, unless documentation of infertility exists.
• Mentally competent, ability to understand and willingness to sign the informed consent form.
• Patients with persisting, non-hematologic, non-infectious toxicities from prior treatment must be ≤ Grade 2 and must be documented as such.
• Laboratory values ≤ 2 weeks prior to the start of study treatment must be the following:
• Aspartate aminotransferase [AST/SGOT] ≤ 5x upper normal limit [UNL],
• Alanine aminotransferase [ALT/SGPT] ≤ 5x UNL
• Bilirubin ≤ 3x UNL
• Albumin ≥ 2.0 g/dL or ≥ 20 g/L
• Serum creatinine ≤ 2.0 mg/dL
• Presence of central venous catheter or willing to have central venous access placed.

Exclusion criteria

• Patients with active central nervous system (CNS) or epidural tumor.
• Pregnant persons, or persons of child-bearing potential not using reliable means of contraception (because the teratogenic potential of CPI-613 is unknown).
• Breastfeeding individuals because the potential of excretion of CPI-613 into breast milk. (Note: Breastfeeding individuals are excluded because the effects of CPI-613 on a nursing child are unknown).
• Any condition or abnormality which may, in the opinion of the investigator, compromise the safety of patient.
• Unwilling or unable to follow protocol requirements.
• Patients receiving any other standard or investigational treatment for their cancer, or any other investigational agent for any indication within the past 1 week prior to initiation of CPI-613 treatment with the following exceptions:
• The use of Hydrea or any targeted oral agent is allowed up to the day before initiation of treatment.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Treatment - CPI-613 with Metformin

Experimental group

Description:

Induction therapy with CPI-613 and Metformin (ideally 2 hours prior to start of CPI-613 infusions on days 1-5) for two cycles of treatment. Maintenance therapy with CPI-613 and Metformin (ideally 2 hours prior to start of CPI-613 infusions on days 1-5) until progression, intolerable toxicity of withdrawal of consent.

Treatment:

Drug: Metformin

Drug: CPI 613

Procedure: Bone marrow biopsy

Biological: Blood draws