CPK Levels After LC and Association With Analgesic Modalities

Samsun University

Status: Completed

Conditions: Myotoxicity

Treatments: Other: Standart analgesia plan; Other: İnterfascial plane block

Study type: Observational

Funder types: Other

Identifiers

NCT06508177

SamsunU_LapCholecyst_CK

Details and patient eligibility

About

Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. The investigators aimed to examine plasma creatine phosphokinase (CPK) levels to see whether myotoxicity occurs or not after fascial plane blocks are applied to patients undergoing laparoscopic cholecystectomy.

Full description

During 3 months period all elligible patients undergoing laparoscopic cholecystectomy surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma creatin phosphokinase (CPK) levels will be tested 3 times of all patients(preoperative, postoperative 6th hour, postoperative 24th hour). Data will be analysed and patients will be grouped according to the analgesic modalities used.

Enrollment: 80 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1-3
• Laparoscopic cholecystectomy
• under General Anesthesia

Exclusion criteria

• Morbidly obesity or cachexia
• local anesthetic allergies
• myopathies
• coagulopathies
• Obstructive sleep apne syndrome
• hearth diseases
• liver diseases
• kidney diseases
• thyroid-parathyriod dieseas
• hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
• pregnancy

Trial design

80 participants in 2 patient groups

Interfascial plane blocks

Description:

Patients who are preferred to apply interfascial plane blocks as part of multimodal analgesia in the postoperative analgesia plan will be evaluated in this group.

Treatment:

Other: İnterfascial plane block

Other: Standart analgesia plan

Control

Description:

Multimodal analgesia plans that does not include interfascial plane blocks

Treatment:

Other: Standart analgesia plan