Cranberry Consumption Improves γδ T Cell Function

University of Florida

Status: Completed

Conditions: Healthy

Treatments: Other: Cranberry Beverage; Other: Placebo Beverage

Study type: Interventional

Funder types: Other

Identifiers

NCT01713829

CB-472-2012

Details and patient eligibility

About

The purpose of this study is to determine the extent to which consuming a cranberry beverage modifies immune function, specifically related to γδ T cells and other innate immune cells. It is hypothesized that cranberry components will interact with immune cells to activate signaling pathways that enhance cell function. Enhanced immune cell function should result in reduced number, duration, and severity of cold and flu symptoms.

Enrollment: 52 patients

Sex: All

Ages: 21 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• between 21 and 35 years of age and in good health
• have a BMI between 18.5 and 29.9
• willing to consume the study beverage for 12 weeks
• willing to have a small amount of blood drawn two times
• willing to stop consuming tea and immune-enhancing dietary supplements (e.g. antioxidant-, probiotic-, or flavonoid-containing supplements, fish oil, and Echinacea) before and during the 12 weeks of the study
• willing to consume no more than 7 servings of fruits and vegetables a day
• willing to limit your alcohol consumption to no more than 14 glasses a week
• willing to limit your yogurt consumption to no more than one 8oz. serving per day

Exclusion criteria

• have food allergies
• have hypertension
• taking non-steroidal anti-inflammatory drugs on a chronic basis, antibiotics, or immunosuppressive drugs
• sensitive to aspirin or prone to kidney stones
• current smoker
• pregnant, lactating, or on hormone therapy, except for birth control pills

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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52 participants in 2 patient groups, including a placebo group

Cranberry Beverage

Experimental group

Description:

Cranberry Beverage is provided in an 8 oz daily beverage consumed once daily for 12 weeks

Treatment:

Other: Cranberry Beverage

Placebo Beverage

Placebo Comparator group

Description:

The placebo beverage looks like the active arm and is given in the same way but contains no active ingredient.

Treatment:

Other: Placebo Beverage