Cranberry Enhances Human Immune Function and Reduces Illness

University of Florida

Status

Completed

Conditions

Healthy Humans

Treatments

Dietary Supplement: Beverage made to look like the cranberry beverage

Dietary Supplement: Beverage made from cranberry compounds

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01398150

CB-79545

Details and patient eligibility

About

The purpose of this study is to determine whether consuming a beverage made with cranberry polyphenols and proanthocyanidins is effective in modifying immune function by enhancing immune cell proliferation, cytokine production, and antioxidant capacity. If immune cell proliferation is improved, the subjects are expected to have fewer cold and flu symptoms.

Full description

The study will be conducted as a randomized, double blind, placebo-controlled parallel trial. Subjects will be randomly assigned to either the Treatment (cranberry beverage) group or the Placebo group and each will be instructed to consume the test beverages twice a day for 70 days. The beverage is not commercially prepared juice, but is a beverage prepared with an extract of cranberry that contains polyphenols and proanthocyanidins. Blood is taken at baseline, and day 70. Subjects are given a diary to keep a record of their cold and flu symptoms. Serum is used to determine the antioxidant activity by the ORAC method. Peripheral blood mononuclear cells are isolated from the blood draw and used fresh, cultured for 24 hours or cultured for 10 days. Freshly isolated cells will be used to determine αβ-T, γδ-T, B and NK cell numbers and then cultured in autologous serum for 10 days to determine how well they proliferate. The supernatant of 24 hour cultures will be used for cytokine determination. If cells have been primed by the beverage made with cranberry compounds, the investigators expect the cells to proliferate to a greater extent and have modified cytokine production compared to placebo. If the beverage made with cranberry compounds enhances the proliferation of one or more of these cell types (αβ-T, γδ T, B or NK cell), then it is possible that there will be fewer cold and flu symptoms in the group consuming the cranberry beverage. Incidence of illness is not expected to change, only the severity of the illness.

Enrollment

54 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Health male or non-pregnant female
Between the ages of 21 and 50
BMI between 18 and 35

Exclusion criteria

High blood pressure define as 140/90
Ongoing or chronic illness or infection
On hypertensive medication, immunosuppressive drugs, antibiotics, or chronic use of NSAIDS
Taking plant-based dietary supplements, antioxidant supplements, or probiotics
Vegetarian or strict vegan
Consume more than 1 cup of tea (iced or hot) per day
Consumes more than 2 glasses of alcoholic beverages per day
Consume more than 7 fruits and vegetables per day