Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults

Laval University

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Cranberry extract capsules

Study type: Interventional

Funder types: Other

Identifiers

NCT05931237

Metacann

Details and patient eligibility

About

Consumption of (poly)phenols is recognized to have beneficial effects on health. However, heterogeneous results are obtained in clinical trials due to high inter-individual variability. The objective of this pilot study is to characterize the inter-individual variability associated with the interaction of (poly)phenols from cranberry and gut microbiota.

The participants (n=39) of this study are healthy adults aged between 23 and 63 years old and consumed cranberry extract rich in (poly)phenols for 4 days. Plasma, urine and feces were collected to quantify gut microbial (poly)phenols metabolites and to profile the fecal microbiota.

Enrollment: 39 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Stable weight
• Stable or no medication
• Stable diet
• Stable physical activity

Exclusion criteria

• Pregnant women
• Antibiotic and/or probiotic use three months prior to the study
• Smokers

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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39 participants in 1 patient group

Cranberry extract capsules (PREBIOCRAN(TM))

Experimental group

Description:

Cranberry extract capsules consumed twice a day providing 82.3 mg of flavan-3-ols daily.

Treatment:

Dietary Supplement: Cranberry extract capsules