Cranberry Juice in the Prevention of Urinary Tract Infections in Children

University of Oulu

Status: Completed

Conditions: Urinary Tract Infections

Treatments: Biological: Cranberry juice; Biological: Placebo juice

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00638170

72/2001

Details and patient eligibility

About

The objective of the study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.

Full description

Five percent of children have at least one UTI episode and 30% of these episodes recur. Recurrences and the risk of renal damage are indications for long term antimicrobial prophylaxis, but emerging antimicrobial resistance underlines the need for alternatives. The bacteria causing urinary tract infection arise from the stools. Dietary changes can alter the balance of faecal bacteria. Vaccinium berries and products containing lactobacilli have been shown to act against the coliform bacteria that cause most urinary tract infections. In our previous study cranberry juice was effective in preventing symptomatic recurrences of urinary tract infections in women. The objective of our study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.

Enrollment: 262 estimated patients

Sex: All

Ages: 1 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Urinary Tract Infection 0-2 months priorly

Exclusion criteria

• Antibiotic Prophylaxis

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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262 participants in 2 patient groups, including a placebo group

A

Active Comparator group

Description:

Cranberry juice

Treatment:

Biological: Cranberry juice

B

Placebo Comparator group

Description:

Placebo juice

Treatment:

Biological: Placebo juice