Cranberry-lingonberry Juice Started During Acute Infection in Prevention of Urinary Tract Infections in Children

University of Oulu

Status: Completed

Conditions: Urinary Tract Infection; Cystitis; Pyelonephritis

Treatments: Other: Cranberry-lingonberry juice; Other: Placebo juice

Study type: Interventional

Funder types: Other

Identifiers

NCT01861353

EETTMK74/2012

Details and patient eligibility

About

Cranberry and cranberry-lingonberry juice prevented urinary tract infections in children and in adults in our earlier clinical trials. The preventive effect was, however, observed late in the follow-up and the next recurrence was not prevented in children. The investigators hypothesize that cranberry-lingonberry juice should be started already during the antimicrobial treatment of acute urinary tract infection in order to maximize the preventive efficacy of the juice. In addition, the investigators aim to find the explanation for the efficacy of cranberry-lingonberry juice by analyzing the concomitant changes in the chemical composition of urine and feces as well as the changes of gut microbiota.

Enrollment: 113 patients

Sex: All

Ages: 1 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Recent confirmed urinary tract infection, diagnosed in Oulu University Hospital or Oulu Health Care Center
• Age 1-16 years

Exclusion criteria

• Continuous antimicrobial prophylaxis
• Age < 12 months or > 16 years
• Severe congenital kidney or other urinary tract anomaly in ultrasound

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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113 participants in 2 patient groups, including a placebo group

Cranberry-lingonberry juice

Experimental group

Description:

Cranberry-lingonberry juice. Cranberry 12.8%, Lingonberry 12.4%, together 38g/l, contains added sugars 10g/dL. Dose is 5 mL/kg/day, max. 300 ml/day per day. Juice was manufactured and donated by Eckes-Granini, Finland

Treatment:

Other: Cranberry-lingonberry juice

Placebo juice

Placebo Comparator group

Description:

Contains no cranberry or lingonberry extracts. Added sugars 10g/dL (same as in the active juice group). Contains natural cranberry flavour and red anthocyanin colour. Contains 5.5 g/L citric acid. Has been tested by chemists and does not contains PAC-compounds which are thought to be the main active compound in cranberry juice. Placebo juice was manufactured by Eckes-Granini. Dose is 5 mL/kg/day, max. 300 mL/day.

Treatment:

Other: Placebo juice