Cranberry (Poly)Phenol Consumption on Vascular Function

Heinrich-Heine University, Duesseldorf

Status: Completed

Conditions: Healthy Young

Treatments: Dietary Supplement: cranberry (poly)phenol containing supplement; Dietary Supplement: Placebo comparator: cranberry (poly)phenol deprived supplement

Study type: Interventional

Funder types: Other

Identifiers

NCT02764749

15-042 (Other Identifier)

Cranberry

Details and patient eligibility

About

Epidemiological studies suggest that the consumption of (poly)phenols rich foods such as cocoa, tea, fruits and vegetables is associated with lower blood pressure, reduced cholesterol and decreased cardiovascular risk. Cranberries are a rich source of (poly)phenols, including anthocyanins, proanthocyanidins and phenolic acids. Whether cranberries can improve vascular function when given over relevant time periods and in relevant populations is not known. Therefore, it is the overall hypothesis of the study proposal that chronic consumption of cranberries can improve endothelial function, a prognostically validated surrogate of cardiovascular risk. This study also aims to reveal which cranberry (poly)phenols have bioactive properties in healthy men. Consequently, plasma and urine metabolite peaks will be correlated with vascular outcomes and genome-wide expression microarrays will be performed to reveal cell signaling pathways associated with cranberry (poly)phenol-mediated cardioprotective events.

Enrollment: 40 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy male subjects (no clinical signs or symptoms of CVD)
• Young >18 years, <35 years

Exclusion criteria

• CVD
• acute inflammation
• cardiac arrhythmia
• renal failure
• heart failure (NYHA II-IV)
• diabetes mellitus
• CRP > 1 mg/dl
• malignant disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

freeze dried powder whole cranberry dissolved in water

Experimental group

Description:

Dietary Supplement: freeze dried cranberry powder

Treatment:

Dietary Supplement: cranberry (poly)phenol containing supplement

freeze dried cranberry deprived powder dissolved in water

Placebo Comparator group

Description:

Placebo comparator: freeze dried cranberry deprived powder

Treatment:

Dietary Supplement: Placebo comparator: cranberry (poly)phenol deprived supplement